Printed trail information are available at some of the access sites and provide detailed information and maps to encourage safe exploration. They also include background on the ecology and natural and human history of the river corridor and its connection to the Chesapeake Bay. Low-impact camping guidelines help visitors tread lightly on the river's resources. Campgrounds, outfitters, and boating stores in and near the trail corridor will also be listed. Perhaps most importantly, the guide includes explicit instructions on how to get more involved with watershed restoration and stewardship.

The River Trail is managed in partnership by PA Dept. of Conservation & Natural Resources, the PA Fish & Boat Commission, the City of Harrisburg, and a nonprofit Susquehanna River Trail Association, Inc. Volunteer individuals or groups can adopt islands to serve as stewards for maintenance, monitoring resource impacts, and tracking public use. Management techniques and use levels will continually be evaluated to insure resource protection and a positive experience for the visitor.